Engineered proteins to study cells, detect and treat disease
We engineer proteins to create tools for controlling and observing biological processes. We apply thermodynamics, reaction kinetics, and transport phenomena to design assays for characterizing biomolecules, and screen for desired function. We apply our tools to decipher protein functions in cells and identify function of specific cell types in multicellular systems. We aim to identify mechanisms that lead to complex biological system function and its disorders, and novel therapeutic targets.
June 2018 - Monika passed the qualifying exam. Congratulations!
March 2018 - Dan Li gave a talk at the American Chemical Society meeting.
October 2017 - Monika Arbaciauskaite (CBE) joined the group as a PhD student.
August 2017 - Our collaboration with Dr. Yu Lei was funded by the National Science Foundation.
April 2017 - Dr. Cho gave a talk on high affinity phospho-tau specific antibodies at the 2017 American Chemical Society national meeting.
January 2017 - Undergraduate student Nicholas Wolslegel joined group for independent research.
September 2016 - Undergraduate students Tori Danis, Jerry Dinan, Jennifer Skoog, Kayla Sagan, Jacob Chicano joined group for independent research.
September 2016 - Azady Pirhanov (BME) joined the group as a PhD student.
August 2016 - Our project on anti-acetyl tau antibodies was funded by the National Institues of Health.
July 2016 - Our group participated in UConn's daVinci project for the third year. We regularly host the 'Genetic Engineering and Synthetic Biology' workshop during this weeklong event.
June 2016 - Dr. Cho received a 'Best of BIOT' award from the American Chemical Society.
March 2016 - Dr. Cho gave a talk on our antibody specificity engineering method at the American Chemical Society national meeting.
March 2016 - Our protocol entitled 'An Optimized Calcium-Phosphate Transfection Method for Characterizing Genetically Encoded Tools in Primary Neurons' was published in Methods in Molecular Biology.
March 2016 - Our review on optogenetics entitled 'Optogenetics: Basic Concepts and Their Development' was published in Methods in Molecular Biology.
January 2016 - Undergraduate students Daniel Wackelin and Moe Uddin joined group for independent research.
Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents (Journal of Biological Chemistry, 2019)
Directed Evolution of a Picomolar Affinity High Specificity Antibody Targeting Phosphorylated Tau (Journal of Biological Chemistry, 2018)
An Optimized Calcium-Phosphate Transfection Method for Characterizing Genetically Encoded Tools in Primary Neurons (Methods in Molecular Biology, 2016).
Optogenetics: Basic Concepts and Their Development (Methods in Molecular Biology, 2016).
Genetically Encoded Tools: Bridging the Gap between Neuronal Identity and Function (ACS Chemical Neuroscience, 2015).
Natural photoreceptors and their application to synthetic biology (Trends in Biotechnology, 2015).