About Us

Engineered proteins to study cells, detect and treat disease

We engineer proteins to create tools for controlling and observing biological processes. We apply thermodynamics, reaction kinetics, and transport phenomena to design assays for characterizing biomolecules, and screen for desired function. We apply our tools to decipher protein functions in cells and identify function of specific cell types in multicellular systems. We aim to identify mechanisms that lead to complex biological system function and its disorders, and novel therapeutic targets.

News

April 2021 - Shiyao successfully defended her PhD thesis. Congratulations, Dr. Wang!

February 2021 - Monika's review paper on Phospho-tau antibodies and immunoassays was accepted for publication in Antibody Therapeutics.

January 2021 - Azady's paper on Sinorhizobium optogenetics was accepted for publication in ACS Synthetic Biology.

March 2020 - Our group received a new grant from NIH - NIA.

January 2020 - Erik Ammermann passed his PhD qualifying exam. Congratuations!

November 2019 - Erik Ammermann joined the lab as a PhD student. Welcome!

September 2019 - Our group received a new grant from the Alzheimer's Association. Thank you very much for your support!

September 2019 - Shiyao's paper on yeast surface display of human tau was accepted for publication in Biotechnology Progress.

July 2019 - Our group received a Research Excellence Program grant from UConn.

July 2019 - Dan's paper on phospho-tau antibody specificity measurement was accepted for publication in the Journal of Neurochemistry.

July 2019 - Dan Li successfully defended her PhD thesis. Congrats Dr. Li!

April 2019 - Dr. Cho gave an invited talk at the PEGS Boston meeting.

March 2019 - Dr. Cho gave a talk at the American Chemical Society annual meeting.

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Highlights

High specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples (Antibody Therapeutics, 2021)

Optogenetics in Sinorhizobium meliloti enables spatial control of exopolysaccharide production and biofilm structure (ACS Synthetic Biology, 2021)

Yeast surface display of full-length human microtubule-associated protein tau (Biotechnology Progress, 2020)

High specificity of widely used phospho‐tau antibodies validated using a quantitative whole‐cell based assay (Journal of Neurochemistry, 2020)

Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents (Journal of Biological Chemistry, 2019)

Directed Evolution of a Picomolar Affinity High Specificity Antibody Targeting Phosphorylated Tau (Journal of Biological Chemistry, 2018)