Engineered proteins to study cells, detect and treat disease
We engineer proteins to create tools for controlling and observing biological processes. We apply thermodynamics, reaction kinetics, and transport phenomena to design assays for characterizing biomolecules, and screen for desired function. We apply our tools to decipher protein functions in cells and identify function of specific cell types in multicellular systems. We aim to identify mechanisms that lead to complex biological system function and its disorders, and novel therapeutic targets.
December 2022 - Bahareh successfully defended her PhD thesis. Congratulations!
October 2022 - Azady successfully defended his PhD thesis. Congratulations!
October 2022 - Yongku will be giving a talk at the 'Discovery on Target' conference PROTACs and Molecular Glues - EMERGING DEGRADER MODALITIES in Boston, MA.
July 2022 - Monika successfully defended her PhD thesis. Congratulations!
June 2022 - Bahareh's paper on Degradation-driven protein level oscillations was accepted for publication in Biosystems.
April 2022 - Azady will be giving a talk at PEGS Boston:
January 2022 - Katelyn and Cristian joined the group as undergraduate researchers. Welcome!
November 2021 - Monika gave a presentation on her yeast biopanning work at AIChE.
September 2021 - Rayne Santiago joined the group as an undergraduate researcher. Welcome!
April 2021 - Shiyao successfully defended her PhD thesis. Congratulations, Dr. Wang!
February 2021 - Monika's review paper on Phospho-tau antibodies and immunoassays was accepted for publication in Antibody Therapeutics.
January 2021 - Azady's paper on Sinorhizobium optogenetics was accepted for publication in ACS Synthetic Biology.
Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion (bioRxiv, 2022)
Degradation-driven protein level oscillation in the yeast Saccharomyces cerevisiae (Biosystems, 2022)
Yeast biopanning for detecting antibody binding to site-specific phosphorylations in tau (bioRxiv, 2022)
High specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples (Antibody Therapeutics, 2021)
Optogenetics in Sinorhizobium meliloti enables spatial control of exopolysaccharide production and biofilm structure (ACS Synthetic Biology, 2021)