About Us

Applying protein engineering to combat neurodegenerative diseases

We aim to develop novel biotherapeutics and biomarkers by studying how proteins cause toxicity and coming up with strategies to prevent it.

More about our research

News

**We have multiple open positions. If you are interested in joining the group as a PhD student or a postdoc, please contact cho at uconn.edu

May 2024 - Azeem joined the group as a PhD student. Welcome!

March 2024 - Fatemeh joined the group as a PhD student. Welcome!

October 2023 - Cristian joined the group as a full-time research specialist. Welcome!

September 2023 - Katelynn and Youn joined the lab as undergraduate researchers. Welcome!

June 2023 - Monika's paper Yeast biopanning against site-specific phosphorylations in tau was published in Protein Engineering Design and Selection.

December 2022 - Bahareh successfully defended her PhD thesis. Congratulations!

October 2022 - Azady successfully defended his PhD thesis. Congratulations!

October 2022 - Yongku will be giving a talk at the 'Discovery on Target' conference PROTACs and Molecular Glues - EMERGING DEGRADER MODALITIES in Boston, MA.

July 2022 - Monika successfully defended her PhD thesis. Congratulations!

June 2022 - Bahareh's paper on Degradation-driven protein level oscillations was accepted for publication in Biosystems.

April 2022 - Azady will be giving a talk at PEGS Boston:
https://www.pegsummit.com/engineering-antibodies.

January 2022 - Katelyn and Cristian joined the group as undergraduate researchers. Welcome!

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Highlights

Yeast biopanning against site-specific phosphorylations in tau (Protein Engineering Design & Selection, 2023)

Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion (bioRxiv, 2022)

Degradation-driven protein level oscillation in the yeast Saccharomyces cerevisiae (Biosystems, 2022)

High specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples (Antibody Therapeutics, 2021)